Braco-19 trihydrochloride
CAS No. 1177798-88-7
Braco-19 trihydrochloride ( BRACO19 3HCl )
产品货号. M27756 CAS No. 1177798-88-7
BRACO19 is a telomerase inhibitor. It also stabilizes G-quadruplexes, targeting telomeric G-quadruplexes.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Braco-19 trihydrochloride
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述BRACO19 is a telomerase inhibitor. It also stabilizes G-quadruplexes, targeting telomeric G-quadruplexes.
-
产品描述BRACO19 is a telomerase inhibitor. It also stabilizes G-quadruplexes, targeting telomeric G-quadruplexes.(In Vitro):The IC50 for BRACO-19 trihydrochloride (1.0-10 μM) in UXF1138L cells is 2.5 μM, the IC100 is 5 μM. BRACO-19 trihydrochloride (1 μM) dramatically reduces the expression of nuclear hTERT. BRACO-19 trihydrochloride (0-40 μM) dose-dependently decreases the AdV virus growth in eGFP-transinfected HEK 293 cells. BRACO-19 trihydrochloride (0-150 μM) decreases band intensity in an increasing concentration-dependent manner.(In Vivo):In nude mice established UXF1138LX Xenografts, BRACO-19 trihydrochloride (2 mg/kg; i.p.) significantly inhibits tumor growth and shows marked single-agent antitumor activity. some animals in the group shows complete regressions (5 of 12 tumors).
-
同义词BRACO19 3HCl
-
通路Others
-
靶点Other Targets
-
受体Angiotensin II
-
研究领域——
-
适应症——
化学信息
-
CAS Number1177798-88-7
-
分子量703.2
-
分子式C35H46Cl3N7O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Pei Yu, et al. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica. 2017 Jan;47(1):11-19.
产品手册
关联产品
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
-
Substance P 7-11(TFA...
Substance P 7-11(TFA) is a C-terminal fragment of Substance P .
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.