Braco-19 trihydrochloride ( BRACO19 3HCl )

产品货号. M27756 CAS No. 1177798-88-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Braco-19 trihydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BRACO19 is a telomerase inhibitor. It also stabilizes G-quadruplexes, targeting telomeric G-quadruplexes.
产品描述

BRACO19 is a telomerase inhibitor. It also stabilizes G-quadruplexes, targeting telomeric G-quadruplexes.(In Vitro):The IC50 for BRACO-19 trihydrochloride (1.0-10 μM) in UXF1138L cells is 2.5 μM, the IC100 is 5 μM. BRACO-19 trihydrochloride (1 μM) dramatically reduces the expression of nuclear hTERT. BRACO-19 trihydrochloride (0-40 μM) dose-dependently decreases the AdV virus growth in eGFP-transinfected HEK 293 cells. BRACO-19 trihydrochloride (0-150 μM) decreases band intensity in an increasing concentration-dependent manner.(In Vivo):In nude mice established UXF1138LX Xenografts, BRACO-19 trihydrochloride (2 mg/kg; i.p.) significantly inhibits tumor growth and shows marked single-agent antitumor activity. some animals in the group shows complete regressions (5 of 12 tumors).
同义词

BRACO19 3HCl
通路

Others
靶点

Other Targets
受体

Angiotensin II
研究领域

——
适应症

——

CAS Number

1177798-88-7
分子量

703.2
分子式

C35H46Cl3N7O2
纯度

>98% (HPLC)
溶解度

——
SMILES

Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
化学全称

——

1.Pei Yu, et al. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica. 2017 Jan;47(1):11-19.

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